There’s a neuron for depression or, more precisely, resiliency to the chronic stress that can cause depression. What makes some of us vulnerable to depression and others not? Is it exposure to chronic stress or a preceding susceptibility? The answer may lie in a neuron promoting resilience.
Ludmer researcher Dr Rose Bagot and colleagues at Icahn School of Medicine and Stanford University have identified a neuron that may explain why some people are more resilient to depression induced by chronic stress: the medium spiny neuron containing D1 dopamine receptor (D1-MSN). Resilient mice had increased baseline D1- MSN activity and increased calcium transients prior to stress exposure.
Recognizing why chronic stress causes only a subset of individuals to become depressed is critical to understanding depression on a basic level and to developing treatments that increase resilience.
Read the article: Jessie Muir, Zachary S Lorsch, Charu Ramakrishnan, Karl Deisseroth, Eric J Nestler, Erin S Calipari, Rosemary C Bagot. 2017. In Vivo Fiber Photometry Reveals Signature of Future Stress Susceptibility in Nucleus Accumbens. Neuropsychopharmacology, August 2017; doi: 10.1038/npp.2017.122
Learn more about the Ludmer researcher(s) in this study: Dr Rose Bagot @ Department of Psychology, McGill University
- Department of Psychology, McGill University, Montreal, QC, Canada
- Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- Department of Bioengineering, Stanford University, Stanford, CA, USA
McGill News, August 1 2017 (interview with Dr Bagot): www.pending