MCIN lecture – Spatiotemporal subtypes of Alzheimer's disease using tau-PET imaging
Lecturer: Jacob Vogel
Friday, January 24, 2020 from 13:00-14:00
Location: De Grandpre Communications Centre auditorium, @ the Montreal Neurological Institute-Hospital (The Neuro), 3801 University St, Montréal, QC, H3A 2B4
Who: Open to university faculty, students and staff and business professionals, in Montreal and beyond, working in related areas in Alzheimer’s disease, neuroimaging and neuroinformatics.
Abstract: Alzheimer’s disease (AD) is characterized by pathological aggregation of two different, aberrantly conformed proteins, beta-amyloid and tau. Classic pathological studies based on extensive autopsy cohorts have taught us that these proteins, particularly tau, spread through the cerebral cortex in a specific and highly stereotyped manner. However, rare subtypes of AD with divergent patterns of tau deposition have been reported and some studies have also reported variation even in typical AD.
Pathology studies suffer from limitations that make identifying pathological subtypes challenging, including limited spatial sampling and semi-quantitative measurement strategies. However, neuroimaging subtyping studies have also been limited by non-specific measurements and methodological challenges that I will discuss in detail.
Jacob Vogel will report on the application of a novel spatiotemporal subtyping approach to a large (n=1764), multisite dataset of tau-PET images. He will describe the phenotypic presentation of the subtypes identified, how they conform with and diverge from previous literature, and how these results fit with the current models of AD pathological progression.
BIO: Jake Vogel is a PhD student in Dr Alan Evans’ lab, studying models to explain the pattern of brain pathology in Alzheimer’s disease using human neuroimaging. Jake is a Vanier Scholar, and worked as a Research Associate in Bill Jagust’s PET imaging lab in UC Berkeley prior to joining McGill.
The McGill Centre for Integrative Neuroscience (MCIN) constitutes the neuroinformatics component of the Ludmer Centre for Neuroinformatics & Mental Health.
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