Friday, 23 August 2019 – 10:00 – 11:00 am
Dr. Andreazza will provide an overview of where we are and where we are going in the study of energy metabolism in the diagnosis and treatment of bipolar disorder. Her lecture will address the question:
“Is mitochondrial function the cause of neurotransmission changes in bipolar disorder?”
She will finish by presenting novel models, including the use of brain organoids, to understand the involvement of the energy metabolism on neurotransmission.
Location: Bowerman Room
Dobell Pavilion (1st floor, building #21 on map)
Douglas Mental Health University Institute,
6875 LaSalle Boulevard, Verdun, QC, H4H 1R3
Open to Douglas Hospital and McGill faculty and students.
Mitochondria are the cell’s powerhouse. Impaired mitochondrial function can damage the body’s highly metabolically active tissues. Among these, the brain is the highest energy consumer, accounting for 20% of the body’s total energy budget just to power neuronal function, including neuronal electrical activity and neurotransmission. Sustained mitochondrial dysfunction can have profound effects on neurotransmission and may contribute substantially to changes in neuronal circuits in the brain that underlie cognition, memory and other forms of neuronal plasticity.
One plausible hypothesis in bipolar disorder is the failure of mitochondrial function to support adequate neurotransmission and synaptic plasticity, potentially affecting mood regulation, memory, and executive function. This hypothesis is supported by studies in bipolar disorder showing higher (1) frequency of mtDNA mutations; (2) polymorphisms in autosomal mitochondrial complex I genes; (3) lactate levels; (4) reactive oxygen species (ROS) production; and (5) downregulation of NDUFS7 (an essential mitochondrial complex I subunit). One of the most intriguing clinical observations is that individuals with mitochondrial disease commonly present with psychiatric symptoms.
For more information, please contact the organizer, Ludmer Centre Researcher Patricia Pelufo Silveira.
Sponsored by the Douglas Hospital and the Ludmer Centre for Neuroinformatics & Mental Health