How does childhood stress establish the groundwork for adult depression? Researchers at the Icahn School of Medicine at Mount Sinai and Ludmer researcher Dr Rose Bagot found genes regulated by the transcription factor OTX2 – a protein controlling the rate of transcription of genetic information from DNA to messenger RNA – primed the response toward adult depression.
In a study of mice, they found young mice are especially susceptible to stress during a critical growth period that also made them less resilient to stress in adulthood. Understanding the impact of stress during this critical window may, through further research, lead to timely interventions aimed at mitigating susceptibility.
Read the article: Catherine J. Peña1, Hope G. Kronman, Deena M. Walker, Hannah M. Cates, Rosemary C. Bagot, Immanuel Purushothaman, Orna Issler, Yong-Hwee Eddie Loh, Tin Leong, Drew D. Kiraly, Emma Goodman, Rachael L. Neve, Li Shen, Eric J. Nestler. Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2. Science 16 Jun 2017: Vol. 356, Issue 6343, pp. 1185-1188 DOI: 10.1126/science.aan4491
Ludmer Centre Primary Investigator: Dr Rose Bagot @ Department of Psychiatry, McGill University
- Department of Psychology, McGill University, Montréal, Canada
- Department of Psychiatry and the Fishberg Department of Neuroscience, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, USA.
- Department of Brain & Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, USA
- Nature Review, July 6, 2017: A sensitive window
- TT news, June 28, 2017: Early stress confers lifelong vulnerability causing alterations in a specific brain region
- ICI Radio-Canada, June 19, 2017: Enfant stressé, adulte plus enclin à la dépression
- La Press, June 19, 2017: Enfant stressé, adulte plus enclin à la dépression
- Mount Sinai Health System press release, June 14, 2017: Early Stress Exposure Confers Lifelong Vulnerability, Causing Long-Lasting Alterations in a Specific Brain Reward Region